Acute infantile pneumonopathies treated with fosfomycin

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Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases
03:22

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

Published on: March 1, 2024

J Llorens, G Ley, A Forés

    Chemotherapy
    |January 1, 1977
    PubMed

    Insights

    Fosfomycin treatment for acute pneumopathies in children showed favorable outcomes in most cases. Antibiotic levels in sputum and pleural fluid were monitored, with minimal observed toxicity.

    Area of Science:

    • Pediatric Infectious Diseases
    • Pharmacokinetics
    • Respiratory Medicine

    Background:

    • Acute pneumopathies are common childhood respiratory infections.
    • Fosfomycin is an antibiotic with broad-spectrum activity.
    • Understanding fosfomycin's efficacy and pharmacokinetics in pediatric respiratory infections is crucial.

    Purpose of the Study:

    • To evaluate the clinical efficacy and safety of fosfomycin in children with acute pneumopathies.
    • To determine fosfomycin concentrations in plasma, sputum, and pleural fluid.
    • To assess the pharmacokinetic profile of fosfomycin in pediatric patients.

    Main Methods:

    • A study involving 24 children (11 months to 12 years) with acute pneumopathies treated with fosfomycin (200 mg/kg/day).
    • Clinical, radiological, biological, and bacteriological assessments were performed.
    • Fosfomycin levels were measured in plasma, sputum, and pleural fluid (in cases of pleurisy) every 5 days.

    Main Results:

    • Favorable clinical, radiological, and biological outcomes were observed in 21 out of 24 children.
    • Fosfomycin concentrations in sputum showed variable results, averaging 16.5-23.4% of plasma levels, indicating a cumulative effect.
    • Pleural fluid concentrations ranged from 39-50%. One case required treatment suspension due to cutaneous necrosis; otherwise, toxicity was minimal.

    Conclusions:

    • Fosfomycin demonstrates favorable clinical outcomes and acceptable safety in treating pediatric acute pneumopathies.
    • The pharmacokinetic data suggest adequate drug penetration into respiratory secretions and pleural fluid.
    • Alternative administration routes may be preferred due to potential issues with intramuscular injections and phlebitis from intravenous administration in children.

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