Clinical bacteriological evaluation of infantile bacteriuria treated with fosfomycin
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Published on: June 5, 2012
Insights
Fosfomycin effectively treated urinary tract infections in children, showing good tolerance. Most bacterial strains isolated were sensitive to this antibiotic, indicating its therapeutic potential.
Area of Science:
- Pediatric Nephrology
- Infectious Diseases
- Pharmacology
Background:
- Urinary tract infections (UTIs) are common in children, particularly those with congenital renal malformations.
- Antibiotic resistance is a growing concern in treating pediatric UTIs.
- Fosfomycin is a broad-spectrum antibiotic with a favorable safety profile.
Purpose of the Study:
- To evaluate the efficacy and tolerance of fosfomycin in treating simple and complicated UTIs in children.
- To assess the susceptibility of common uropathogens to fosfomycin.
Main Methods:
- A study involving 14 children with UTIs and congenital renal malformations.
- Bacteriological analysis of urine to identify causative strains (E. coli, Proteus sp., Klebsiella sp.).
- Assessment of bacterial sensitivity to fosfomycin using disc diffusion and Minimum Inhibitory Concentration (MIC).
- Administration of fosfomycin at 150 mg/kg/day in four divided doses, primarily orally.
Main Results:
- Out of 25 isolated strains, 76% were sensitive to fosfomycin, and 24% were moderately sensitive (MIC 64-128 µg/ml).
- Fosfomycin treatment resulted in good outcomes in 10 out of 14 cases (71.4%).
- The antibiotic demonstrated good tolerance with no observed secondary effects.
Conclusions:
- Fosfomycin is an effective and well-tolerated antibiotic for treating pediatric UTIs, even in the presence of renal malformations.
- High sensitivity rates to fosfomycin among common uropathogens support its use in this patient population.
- Further research may explore optimal dosing and long-term outcomes.
Abstract:
The therapeutic action of fosfomycin has been studied in a group of 14 children, with simple and complicated infections of the urinary tract with congenital renal malformations. In the bacteriological study of the urine it was observed that the strains most frequently isolated were E. coli, Proteus sp. and Klebsiella sp. Of the 25 strains isolated 76% were sensitive to the disc of 50 mug fosfomycin and 24% moderately sensitive with a MIC of 64 and 128 mug/ml. The doses of fosfomycin used were 150 mg/kg/day in four administrations. In 13 cases it was administered orally alone and in one case orally and intramuscularly. The results have been good in 10 cases (71.4%) and bad in four cases. The antibiotic has shown good tolerance and no secondary effects have been noticed.
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