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Interactions of fosfomycin with other antibiotics
Abstract:
We selected 100 strains of organisms that were isolated in our hospital, which came from pathological products and which had an MIC of fosfomycin of 256 mug/ml or more and belonged to the genera Klebsiella, Pseudomonas, Escherichia coli, Serratia, Enterobacter, Proteus, Acinetobacter, Levinea and Staphylococcus. We have studied the effect of the association of fosfomycin with 15 antibiotics (beta-lactamins, cephalosporins, aminoglycosides, etc.) and 5 chemotherapeutics. The 11 selected strains were studied by the 'chess board' technique in agar. A study was also carried out on the action of fosfomycin on E. coli K12 E711 in the phase of logarithmic growth. The 11 selected strains were studied by the 'chess board' technique in agar. Synergic effect with fosfomycin associated to other antimicrobials was found in 9 strains.
Insights
This study investigated fosfomycin resistance in hospital-isolated bacteria. Combining fosfomycin with other antimicrobials showed synergistic effects in most tested strains, offering potential treatment strategies.
Area of Science:
- Medical Microbiology
- Antimicrobial Resistance
Background:
- High minimum inhibitory concentrations (MICs) of fosfomycin (≥256 µg/ml) were observed in 100 hospital-isolated bacterial strains.
- Resistant strains belonged to key genera including Klebsiella, Pseudomonas, Escherichia coli, and Staphylococcus.
Purpose of the Study:
- To evaluate the synergistic effects of combining fosfomycin with various antibiotics and chemotherapeutics.
- To explore potential therapeutic strategies against multidrug-resistant bacteria.
Main Methods:
- The checkerboard technique was employed to assess the in vitro activity of fosfomycin in combination with 15 antibiotics and 5 chemotherapeutics.
- Studies included 11 selected resistant strains and a specific strain of Escherichia coli K12 E711.
Main Results:
- A synergistic effect was observed in 9 out of the 11 selected strains when fosfomycin was combined with other antimicrobial agents.
- This indicates potential for enhanced efficacy when fosfomycin is used in combination therapy.
Conclusions:
- Combination therapy involving fosfomycin demonstrates synergistic potential against resistant bacterial strains.
- These findings suggest that fosfomycin combination regimens could be a viable approach to combat challenging infections.