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[Lymphocyte transformation test--basis and clinical use]

H Schwenke

    Folia Haematologica (Leipzig, Germany : 1928)
    |January 1, 1978
    PubMed
    Summary
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    The lymphocyte transformation test identifies specific lymphocyte responses to mitogens. This study explores its application in diagnosing conditions like lymphoma and infectious mononucleosis.

    Area of Science:

    • Immunology
    • Cell Biology

    Context:

    • The lymphocyte transformation test (LTT) assesses immune cell function.
    • Unspecific mitogens can selectively stimulate different lymphocyte populations.

    Purpose:

    • To explain the principle and methodology of the LTT.
    • To detail the diagnostic applications of LTT in clinical settings.

    Summary:

    • The study reviews the LTT, focusing on mitogen effects on lymphocyte subsets.
    • Methodological challenges and LTT applications are discussed.
    • Clinical cases involving malign lymphoma, infectious mononucleosis, and polymyositis illustrate LTT utility.

    Impact:

    • Provides insights into immune system assessment using LTT.

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  • Highlights LTT's potential in diagnosing various immune-related and infectious diseases.
  • Offers practical experience for clinicians utilizing LTT.