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A study of African children with prolonged focal seizure and a specific CT scan finding

P M Leary1, B J Cremin, J D Daubenton

  • 1Department of Paediatrics and Child Health, University of Cape Town, South Africa.

Journal of Tropical Pediatrics
|June 1, 1993
PubMed

Insights

Tuberculoma in children presenting with focal seizures may not require tuberculosis treatment if no other evidence of infection is present. Follow-up CT scans showed complete resolution of lesions in all patients, regardless of treatment.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Focal seizures in children can be associated with central nervous system tuberculoma.
  • The necessity of anti-tuberculous therapy for isolated CNS tuberculoma remains a clinical question.

Purpose of the Study:

  • To evaluate the outcomes of children with focal seizures and CT-diagnosed tuberculoma, with and without anti-tuberculous drug therapy.

Main Methods:

  • Prospective study of 25 children with focal seizures and CT-identified tuberculoma.
  • Comparison between 13 children treated with anti-tuberculous drugs and 12 children who received no such therapy.

Main Results:

  • Complete radiological resolution of tuberculoma lesions was observed in all 25 children.
  • No significant difference in lesion resolution was noted between the treated and untreated groups.

Conclusions:

  • Anti-tuberculous drugs may be safely withheld in pediatric cases of focal seizures with CT-diagnosed tuberculoma, provided there is no other evidence of tuberculosis.
  • This finding suggests a potential non-interventional approach for select cases, warranting further investigation.

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