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Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis
D M Norkool1, N B Hampson, R P Gibbons
1Hyperbaric Department, Virginia Mason Hospital, Virginia Mason Clinic, Seattle, Washington.
The Journal of Urology
|August 1, 1993
Summary
Hyperbaric oxygen therapy effectively treated radiation-induced hemorrhagic cystitis in 71% of patients who had not responded to other treatments. This therapy offers a cost-effective solution for refractory cases.
Area of Science:
- Urology
- Oncology
- Hyperbaric Medicine
Background:
- Radiation-induced hemorrhagic cystitis is a debilitating condition.
- It often presents in patients treated for pelvic malignancies.
- Standard treatments frequently fail to resolve symptoms.
Purpose of the Study:
- To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) for radiation-induced hemorrhagic cystitis.
- To assess HBOT as a salvage treatment option.
- To compare the cost-effectiveness of HBOT.
Main Methods:
- A cohort of 14 patients with confirmed radiation-induced hemorrhagic cystitis underwent HBOT.
- Patients had failed prior management and showed no signs of infection or malignancy.
- Follow-up ranged from 10 to 42 months.
Main Results:
- 71% of patients experienced a positive outcome (complete resolution or marked improvement).
- 3 patients with poor outcomes were later diagnosed with recurrent malignancy.
- HBOT cost was comparable to or less than multiple conservative treatments.
Conclusions:
- Hyperbaric oxygen therapy is an efficacious treatment for radiation-induced hemorrhagic cystitis.
- HBOT is a viable option for patients refractory to other management strategies.
- The cost-benefit analysis supports the use of HBOT in selected cases.