Related Experiment Video
Updated: Aug 11, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
[The effect of genetically determined factors on the development and course of sarcoidosis]
Abstract:
Intricate aspects of sarcoidosis course are studied. Examination included 75 Russian patients with sarcoidosis of the respiratory organs: 44 of them had newly diagnosed process and its spontaneous regression and in 31 the disease took a recurrent course. In all patients the HLA system of classes I and II were detected by means of a standard microlymphocytotoxic test; electrophoresis in polyacrylamide and starch gels was used to determine the genotypes of erythrocyte enzymes and/the groups of specific proteins. In sarcoidosis patients the rate of occurrence of antigens B7 and B8 was characteristically increased (22.7 and 27.3%) as compared to the group of healthy subjects (21.5 and 15.1%) and there was a rise of total homozygosity and heterozygosity reduction for the ESD, ACP, PGM-1 loci, which obviously may affect the disease course. Investigations are in progress.
More Related Videos
Related Concept Videos
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Pharmacogenomics: Identification of New Drug Targets
Gene-Environment Interactions
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

