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[Immune reactivity and fibrinolysis in patients with disseminated pulmonary tuberculosis]
Functional interrelations between immune and fibrinolytic systems were studied in 107 patients with disseminated tuberculosis patients. The findings showed a depression in plasminogen activator activity associated with high yield of fibrin degradation products. Lymphocyte blast transformation with PHA decreased, whereas that with PPD increased. Concentrations of IgA and IgG rose in a small drop of IgM in peripheral blood. The above changes were more pronounced in marked clinical symptoms. The results may give rise to further developments in pathogenetic mechanisms of pulmonary tuberculosis and new approaches to its treatment.
Functional interrelations between immune and fibrinolytic systems were studied in 107 patients with disseminated tuberculosis patients. The findings showed a depression in plasminogen activator activity associated with high yield of fibrin degradation products. Lymphocyte blast transformation with PHA decreased, whereas that with PPD increased. Concentrations of IgA and IgG rose in a small drop of IgM in peripheral blood. The above changes were more pronounced in marked clinical symptoms. The results may give rise to further developments in pathogenetic mechanisms of pulmonary tuberculosis and new approaches to its treatment.