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[Pulmonary hypertension]

G Schuler1

  • 1Medizinische Universitätsklinik, Heidelberg.

Zeitschrift Fur Kardiologie
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Pulmonary emboli cause increased pulmonary artery pressure through mechanical obstruction and vasoactive substances. Effective fibrinolytic therapy can normalize elevated pulmonary artery pressures during rest and exercise.

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Area of Science:

  • Cardiovascular Medicine
  • Pulmonary Medicine
  • Hematology

Context:

  • Pulmonary embolism (PE) leads to increased pulmonary artery pressure (PAP).
  • Mechanisms include mechanical obstruction and vasoactive substance release from platelets.
  • PE can cause intrapulmonary shunts, leading to hypoxemia, though normal blood gases do not exclude PE.

Purpose:

  • To elucidate the mechanisms underlying increased pulmonary artery pressure in pulmonary embolism.
  • To describe the hemodynamic consequences of elevated pulmonary artery pressure.
  • To highlight the impact of fibrinolytic therapy on pulmonary hypertension.

Summary:

  • Pulmonary emboli (PE) cause a rapid rise in pulmonary artery pressure (PAP) via mechanical blockage and vasoactive substances from platelets.

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  • This elevation impairs right and left ventricular function due to reduced stroke volume and filling pressures, exacerbated by biventricular interdependence.
  • Intrapulmonary shunting can lead to arterial hypoxemia, but normal arterial blood gases do not rule out significant PE.

    • Impact:

    • Understanding PE pathophysiology is crucial for accurate diagnosis and management.
    • Recognizing hemodynamic changes aids in assessing PE severity.
    • Fibrinolytic therapy demonstrates efficacy in restoring normal pulmonary artery pressures, improving cardiac function.