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Updated: Aug 14, 2026
07:50
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
[Deep venous thromboses--established treatment procedures and new trends]
1Abteilung Innere Medizin III, Medizinische Universitätsklinik und Poliklinik Ulm.
Zeitschrift Fur Kardiologie
|January 1, 1993
Summary
Thrombolysis effectively treats deep venous thrombosis (DVT) by improving vessel recanalization, though it carries a higher bleeding risk than heparinization. Further trials are needed to confirm benefits of new therapeutic strategies for DVT.
Area of Science:
- Vascular Medicine
- Interventional Cardiology
Context:
- Deep venous thrombosis (DVT) of the legs often presents with poor prognosis due to limited collateral circulation.
- Current therapeutic aims include preventing fatal pulmonary embolism, disease progression, recurrence, and post-thrombotic syndrome.
Purpose:
- To evaluate the efficacy and safety of thrombolysis in managing deep venous thrombosis.
- To compare thrombolysis with traditional anticoagulation methods like heparinization.
- To explore novel loco-regional delivery methods for thrombolytic agents.
Summary:
- Thrombolysis offers higher recanalization rates for DVT compared to heparinization but increases hemorrhage risk.
- Streptokinase, urokinase, and tissue plasminogen activator (t-PA) demonstrate complete recanalization in approximately 30% of cases.
- Loco-regional thrombolysis via a foot vein shows comparable recanalization rates to high-dose streptokinase.
Impact:
- Highlights the need for prospective, randomized trials to establish the benefits of thrombolysis and new therapeutic strategies for DVT.
- Emphasizes the significant epidemiologic and economic impact of DVT, underscoring the importance of effective treatment.
- Provides insights into the comparative efficacy and risks of different thrombolytic agents and delivery methods.
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