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Acral lentiginous melanoma

C M Sutherland1, F J Mather, J H Muchmore

  • 1Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112.

American Journal of Surgery
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

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Acral lentiginous melanoma survival rates vary significantly by race and gender. Black men experienced the poorest outcomes, highlighting disparities in treatment effectiveness for this rare melanoma subtype.

Area of Science:

  • Oncology
  • Dermatology
  • Surgical Oncology

Background:

  • Acral lentiginous melanoma (ALM) is a rare subtype of cutaneous melanoma.
  • Treatment of ALM has historically involved surgical interventions like regional perfusion, lesion excision, and lymph node dissection.

Purpose of the Study:

  • To evaluate the survival outcomes of patients with acral lentiginous melanoma treated with a specific surgical protocol.
  • To identify prognostic factors influencing survival in ALM patients, including race, gender, and disease stage.

Main Methods:

  • Retrospective analysis of 82 patients with ALM treated between 1958 and 1990.
  • Surgical treatment included regional perfusion, lesion excision, and lymph node dissection.
  • Multivariate analysis was used to assess the impact of Clark's level, age, race, stage, and sex on survival.

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Main Results:

  • Overall 5-year survival for stage I ALM was 65%, decreasing to 44% at 10 years.
  • Black men had the poorest 10-year survival rate (13%).
  • Increasing Clark's level was strongly associated with decreased survival time; disease stage showed marginal significance.

Conclusions:

  • Survival rates for acral lentiginous melanoma are influenced by race, gender, and tumor characteristics.
  • Disparities in survival outcomes were observed, particularly among black men.
  • Clark's level is a significant prognostic indicator for ALM survival.