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Inactivation of rifampin by Nocardia brasiliensis
1Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Antimicrobial Agents and Chemotherapy
|June 1, 1993
Abstract:
Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.