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In vitro activity of ramoplanin against vancomycin-resistant gram-positive organisms
L A Collins1, G M Eliopoulos, C B Wennersten
1Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.
Antimicrobial Agents and Chemotherapy
|June 1, 1993
Abstract:
In vitro activity of ramoplanin, a cyclic lipoglycopeptide, against 92 vancomycin-resistant gram-positive organisms was evaluated. Ramoplanin demonstrated potent activity against many highly vancomycin-resistant organisms including enterococci (MICs for 90% of strains tested of 0.5 micrograms/ml) and against Lactobacillus spp., Leuconostoc spp., and Pediococcus spp., all of which were inhibited at concentrations of < or = 0.25 micrograms/ml. This drug or a derivative compound merits further investigation as a potential therapeutic agent for infections due to vancomycin-resistant enterococci.