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Amniotic fluid interleukin-8 as a marker for intraamniotic infection
T Puchner1, C Egarter, C Wimmer
1Abteilung für Geburtshilfe und Gynäkologie, Landeskrankenhaus, Vöcklabruck, Austria.
Archives of Gynecology and Obstetrics
|January 1, 1993
Summary
Measuring amniotic fluid Interleukin-8 (AF IL-8) levels can help diagnose intraamniotic infection. Elevated AF IL-8 concentrations are strongly associated with infection in pregnant women.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Biochemistry
Background:
- Intraamniotic infection (IAI) is a significant cause of preterm birth and neonatal complications.
- Accurate and timely diagnosis of IAI is crucial for effective management.
- Biomarkers for IAI diagnosis are actively being investigated.
Purpose of the Study:
- To evaluate the diagnostic value of amniotic fluid Interleukin-8 (AF IL-8) levels for intraamniotic infection.
- To determine if AF IL-8 concentration can differentiate between infected and uninfected pregnancies.
Main Methods:
- Amniotic fluid samples were collected from 80 women.
- AF IL-8 concentrations were measured using a standard assay.
- Patients were categorized based on clinical signs of infection and neonatal outcomes.
Main Results:
- Nine out of twelve patients with conventional signs of infection had AF IL-8 levels >10,000 pg/ml.
- Two patients with neonatal infections also showed AF IL-8 levels >10,000 pg/ml.
- Only one of 66 apparently uninfected patients had an AF IL-8 level >10,000 pg/ml.
Conclusions:
- Elevated AF IL-8 levels (>10,000 pg/ml) are highly indicative of intraamniotic infection.
- AF IL-8 measurement is a valuable tool in the diagnosis of suspected IAI.
- This biomarker may aid in early detection and treatment of IAI.