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Mitroflow pericardial valve: long-term durability

D Y Loisance1, J P Mazzucotelli, P C Bertrand

  • 1Department of Surgical Research, URA CNRS 1431, Hôpital Henri Mondor, Faculté de Médecine, Créteil, France.

The Annals of Thoracic Surgery
|July 1, 1993
PubMed
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This study evaluated the Mitroflow pericardial valve in 199 patients undergoing heart valve replacement. While offering minimal complications, it showed a slightly increased risk of valve failure compared to porcine valves.

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science

Background:

  • Pericardial heart valves are utilized in valve replacement surgery.
  • Assessing the long-term performance and safety of novel valve generations is crucial.

Purpose of the Study:

  • To evaluate the clinical outcomes of the second-generation Mitroflow pericardial valve.
  • To assess the rates of survival, thromboembolic events, and structural valve dysfunction.

Main Methods:

  • A cohort of 199 patients underwent isolated or double-valve replacement with Mitroflow valves.
  • Follow-up extended to 106 months, with 91.5% completeness.
  • Actuarial analysis was used to determine survival and event-free rates.

Main Results:

  • Actuarial survival at 8.5 years was 66%.

Related Experiment Videos

  • Structural valve dysfunction occurred at 3.2%/patient-year, with 63.7% freedom from events at 8.5 years.
  • Rates of thromboembolic events, hemorrhage, and endocarditis were minimal, but valve failure risk was higher than porcine valves.

    • Conclusions:

    • The Mitroflow valve demonstrates favorable hemodynamic properties.
    • Its use is associated with a slightly elevated risk of structural valve failure compared to porcine valves.
    • Long-term data suggests a balance between excellent hemodynamics and a notable risk of valve deterioration.