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Platelet function after total artificial heart replacement: clinical application and experiment

M R Mueller1, A Salat, S Pulaki

  • 1Department of Surgery , University of Vienna, Austria.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|May 1, 1993
PubMed
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Calf studies of artificial hearts reveal similar platelet function patterns to humans, aiding in predicting critical treatment phases. This research helps improve artificial heart safety by understanding platelet behavior post-implantation.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Hematology

Background:

  • Thromboembolic events complicate mechanical circulatory support with artificial blood pumps.
  • Understanding patient-specific mechanisms of these events is crucial for improving clinical outcomes.

Purpose of the Study:

  • To evaluate the utility of calf animal models in artificial heart research.
  • To compare platelet reactivity in calves with human patients receiving total artificial hearts.

Main Methods:

  • 10 calf experiments and 3 human total artificial heart implantations were conducted.
  • Platelet reactivity was assessed using in vitro collagen-induced whole blood aggregometry, radioimmunoassay, and scanning electron microscopy over 10 days.

Main Results:

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  • A similar periodicity in platelet function was observed in both human and animal recipients.
  • Platelet function improvement preceded platelet count recovery in the early postoperative period.
  • Exaggerated platelet responses to aggregative agents occurred on days 3 and 7 post-implantation.

Conclusions:

  • Calf models provide valuable data comparable to human clinical applications for artificial heart studies.
  • The findings suggest predictable patterns in platelet function and count following total artificial heart replacement.
  • This research may aid in identifying critical phases for patient management during artificial heart therapy.