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Study of potassium citrate treatment of crystalluric nephrolithiasis
M K Khanniazi1, A Khanam, S A Naqvi
1Department of Nephro-Urology, Jinnah Post Graduate Medical Centre, University of Karachi, Pakistan.
Abstract:
Patients with crystalluric nephrolithiasis were treated orally with aqueous potassium citrate solution three times a day with a large quantity of water. After administration of potassium citrate, citric acid (P < 0.001) and potassium (P < 0.001) excretion was significantly increased. Increase in protein (P < 0.05) and uric acid (P < 0.05) excretion in urine revealed their association with the crystallization process. Crystals were absent in 12 (71%) out of 17 patients. Calcium excretion in urine was significantly decreased (P < 0.05). A decrease of calcium ions availability to oxalate ions to form calcium oxalate crystals may result in the prevention of calcium oxalate stone formation.