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Lorazepam toxicity in a premature infant
1Department of Pediatric Pharmacy, School of Medicine, University of North Carolina, Chapel Hill 27514.
The Annals of Pharmacotherapy
|June 1, 1993
Summary
Lorazepam toxicity occurred in a premature infant due to altered drug metabolism. Neonates have depressed glucuronidation, increasing the risk of lorazepam accumulation and adverse events.
Area of Science:
- Neonatal Pharmacology
- Pediatric Toxicology
- Clinical Pharmacy
Background:
- Lorazepam is frequently used in pediatric patients for sedation and anticonvulsant effects.
- Limited data exist on long-term lorazepam safety in neonates.
- Preterm infants may be at higher risk for neurologic toxicity from lorazepam.