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Related Experiment Videos

Polycythaemia, delirium and mania

M Chawla1, J Lindesay

  • 1Towers Hospital, Leicester.

The British Journal of Psychiatry : the Journal of Mental Science
|June 1, 1993
PubMed
Summary

Polycythemia vera can cause delirium and mania. This case highlights the importance of monitoring blood counts for neurological symptom relapse.

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Health technology assessment (Winchester, England)·2013

Area of Science:

  • Neurology
  • Hematology

Background:

  • Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by increased red blood cell mass.
  • Neurological manifestations in PV can be diverse, including delirium and mood disorders.

Observation:

  • A 65-year-old woman presented with delirium attributed to polycythemia vera.
  • She initially improved after venesection but relapsed with mania coinciding with a recurrence of PV.

Findings:

  • The patient experienced distinct neurological episodes (delirium and mania) linked to fluctuations in her polycythemia vera status.
  • Venesection provided temporary relief, but symptom recurrence indicated a direct relationship with disease activity.

Implications:

  • This case underscores the critical need for vigilant monitoring of hematological parameters in patients with PV presenting with neurological symptoms.
  • Recurrent neurological episodes in PV patients may signify disease relapse and necessitate prompt therapeutic intervention.
  • Understanding the link between PV activity and neuropsychiatric symptoms is crucial for comprehensive patient management.

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