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Use of desmopressin to prevent bleeding complications in patients treated with aspirin
1Department of Surgery, Karolinska Institute, Danderyd Hospital, Sweden.
Insights
Aspirin causes bleeding issues that last over a week. Desmopressin effectively prevented postoperative bleeding in patients taking aspirin, normalizing prolonged bleeding times.
Area of Science:
- Pharmacology
- Surgical Medicine
- Hematology
Background:
- Aspirin is a common medication known to induce a prolonged hemorrhagic diathesis.
- This effect of aspirin on bleeding can persist for over a week after drug cessation.
- Managing aspirin-induced bleeding complications is crucial, especially in surgical patients.
Purpose of the Study:
- To investigate the efficacy of desmopressin in preventing postoperative bleeding in patients treated with aspirin.
- To assess the impact of desmopressin on bleeding time in aspirin-treated patients undergoing cholecystectomy.
Main Methods:
- A prospective study involving 12 patients undergoing cholecystectomy and treated with aspirin.
- Six patients received desmopressin, while the other six did not.
- Postoperative bleeding complications and bleeding times were monitored and compared between the groups.
Main Results:
- Five postoperative bleeding complications occurred in the study cohort.
- All bleeding complications were observed in patients who did not receive desmopressin (P < 0.05).
- Desmopressin administration normalized the prolonged bleeding times observed in aspirin-treated patients (P < 0.05).
Conclusions:
- Desmopressin is effective in preventing aspirin-induced postoperative bleeding.
- The vasopressin analogue desmopressin can be safely administered to mitigate bleeding risks in patients on aspirin therapy.
- Desmopressin normalizes bleeding times, offering a viable solution for managing aspirin-related hemorrhagic diathesis.
Abstract:
Aspirin induces a haemorrhagic diathesis that persists for at least 1 week after discontinuation of the drug. The effect of the vasopressin analogue desmopressin was studied in 12 patients treated with aspirin who were undergoing cholecystectomy. Desmopressin was given to six of these patients. There were five postoperative bleeding complications; all occurred in patients who had not received desmopressin (P < 0.05). The bleeding time was prolonged in aspirin-treated patients and normalized by desmopressin (P < 0.05). Desmopressin can be used safely to prevent bleeding induced by aspirin.