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Pharmacological study of the internal and sphincter in patients with chronic anal fissure
F S Regadas1, L K Batista, J L Albuquerque
1Department of Surgery, Federal University of Ceara, Brazil.
The British Journal of Surgery
|June 1, 1993
Abstract:
A pharmacological study of the internal anal sphincter (IAS) was undertaken in patients with chronic and fissure. The sensitivity of the IAS to the contractile effect of phenylephrine and potassium chloride and to relaxation by isoproterenol was evaluated. Supersensitivity of the IAS to relaxation by isoproterenol was noted. Further research is necessary to determine the pharmacological basis of such a disturbance.