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Related Experiment Videos

Intralobar pulmonary sequestration: a clinical and pathological spectrum

L A Nicolette1, A M Kosloske, S A Bartow

  • 1Department of Surgery, University of New Mexico School of Medicine, Albuquerque.

Journal of Pediatric Surgery
|June 1, 1993
PubMed
Summary

Pulmonary sequestration, a lung abnormality, is often considered acquired. However, this study presents cases suggesting intralobar sequestration is congenital, with inflammation developing over time.

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Area of Science:

  • Pulmonology
  • Pediatric Surgery
  • Pathology

Background:

  • Pulmonary sequestration involves abnormal lung tissue with anomalous systemic arterial supply.
  • Intralobar sequestration (ILS) is often diagnosed in older children and inflammation suggests an acquired origin.
  • Previous autopsy studies have supported an acquired etiology for ILS.

Observation:

  • Four pediatric cases of ILS were analyzed, showcasing a range of inflammatory changes.
  • Case presentations spanned from newborns to a 6-year-old, with varying degrees of inflammation.
  • One newborn case showed no inflammation, while others presented with acute and chronic inflammatory changes.

Findings:

  • The presented cases suggest a congenital origin for ILS, contrary to previous theories.

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  • A temporal progression of inflammation was observed, from absent to severe acute and chronic inflammation.
  • This spectrum supports a developmental, rather than solely infectious, etiology for ILS.

    • Implications:

    • The findings challenge the prevailing acquired etiology theory for ILS.
    • Understanding the congenital basis of ILS is crucial for accurate diagnosis and management.
    • Further research into the developmental pathways of ILS is warranted.