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Use of viscosigens to stabilize vitamin B12 solutions against photolysis
C B Grissom1, A M Chagovetz, Z Wang
1Department of Chemistry, University of Utah, Salt Lake City 84112.
Journal of Pharmaceutical Sciences
|June 1, 1993
Abstract:
Glycerol stabilizes cyanocob(III)alamin (vitamin B12) against anaerobic photolysis by a high-intensity UV light source or a low-intensity fluorescent light source. The likely mechanism for stabilization by viscosigens is a decrease in diffusion and an enhancement of radical-pair recombination. Glycerol (25% or greater) stabilizes therapeutic doses of vitamin B12 in single-dose Tubex injection vials against adventitious photolysis by fluorescent light.