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Acetylpolyamines decrease blood pressure, [Ca++]i and isometric force of vascular smooth muscle

L Y Wing1, C F Chan, M J Jiang

  • 1Department of Physiology, National Cheng Kung University, Medical College, Tainan, Republic of China.

The Journal of Pharmacology and Experimental Therapeutics
|July 1, 1993
PubMed
Summary
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Acetylspermine and spermine reduce arterial blood pressure by decreasing intracellular calcium in vascular smooth muscle. This vasodilation effect is dose-dependent and influenced by calcium levels.

Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • Polyamines are essential cellular polycations involved in various biological processes.
  • Acetylation is a key initial step in polyamine metabolism.
  • Understanding the physiological roles of acetylated polyamines is crucial for cell function.

Purpose of the Study:

  • To investigate the effects of acetylated polyamines, specifically acetylspermine and acetylspermidine, on arterial blood pressure.
  • To examine the impact of these compounds on vascular reactivities in rat models.
  • To elucidate the underlying mechanisms of their hypotensive and vasodilatory actions.

Main Methods:

  • Administration of acetylspermine and acetylspermidine to rats at varying doses (12.5–50 mmol/kg b.wt.).

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  • Measurement of mean arterial blood pressure and assessment of vascular smooth muscle responses in isolated aortic rings and tail artery strips.
  • Utilized aequorin-loaded vascular tissues to monitor intracellular calcium levels and isometric force.

    • Main Results:

    • Both acetylspermine and acetylspermidine induced a transient decrease in mean arterial blood pressure.
    • Hypotensive effects followed the order: spermine > acetylspermine > acetylspermidine = spermidine.
    • Acetylspermine and spermine relaxed precontracted arterial preparations by reducing intracellular calcium, an effect counteracted by increased extracellular calcium.

    Conclusions:

    • Acetylspermine and spermine decrease intracellular calcium concentration in vascular smooth muscle.
    • This reduction in intracellular calcium likely mediates vasodilation and contributes to the observed decrease in arterial blood pressure.
    • The findings highlight the significant physiological role of acetylated polyamines in cardiovascular regulation.