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Differential activation of human immunodeficiency virus type 1 and 2 transcription by specific T-cell activation
M C Hannibal1, D M Markovitz, N Clark
1Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109-0650.
Journal of Virology
|August 1, 1993
Abstract:
The human immunodeficiency virus type 1 (HIV-1) and HIV-2 enhancers are induced differentially by physiologic T-cell activation signals. In contrast to that of HIV-1, HIV-2 transcription was quite responsive to stimulation of T cells by antigen presentation but weakly induced by tumor necrosis factor alpha. Like tumor necrosis factor alpha, expression of cloned NF-kappa B subunits strongly activated the HIV-1, but not the HIV-2, enhancer. The differences in response to these physiologic T-cell activation pathways may contribute to the differences in persistence of HIV-1 and HIV-2 infection.