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Related Concept Videos

What is the Endocrine System?00:46

What is the Endocrine System?

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The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
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Endocrine Signaling01:45

Endocrine Signaling

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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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The Endocrine System01:29

The Endocrine System

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The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
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An Overview of the Endocrine System01:10

An Overview of the Endocrine System

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The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Structures of the Endocrine System00:59

Structures of the Endocrine System

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The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
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Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

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A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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[Endocrine hypertension]

R Takeda1

  • 1Second Department of Internal Medicine, School of Medicine, Kanazawa University.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

This review examines adrenal hypertension in Japan, focusing on elderly patients and introducing research on pheochromocytoma and primary aldosteronism. It also presents data suggesting impaired 11 beta-hydroxysteroid dehydrogenase activity in essential hypertension.

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Area of Science:

  • Endocrinology and Hypertension Research
  • Epidemiology of Endocrine Disorders
  • Vascular Biology

Context:

  • Adrenal hypertension, a subset of endocrine hypertension, includes conditions like pheochromocytoma, Cushing's syndrome, and primary aldosteronism.
  • This review honors Prof. Murakami's contributions to hypertensiology in Japan.
  • Focuses on the epidemiological status and clinical characteristics of adrenal hypertension, particularly in aged patients within Japan.

Purpose:

  • To review the current epidemiological status of adrenal hypertension in Japan.
  • To highlight clinical characteristics of aged patients with adrenal hypertension.
  • To introduce current research topics in adrenal hypertension and present novel findings on 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD).

Summary:

  • The paper reviews adrenal hypertension in Japan, emphasizing epidemiological data and clinical features in elderly individuals.
  • It discusses key research areas including pheochromocytoma, Cushing's syndrome, and primary aldosteronism.
  • Presents findings on 11 beta-HSD mRNA expression and activity in vessels, suggesting a role in essential hypertension.

Impact:

  • Provides insights into the prevalence and characteristics of adrenal hypertension in Japan's aging population.
  • Contributes to understanding the pathophysiology of essential hypertension through the lens of 11 beta-HSD impairment.
  • Highlights potential new avenues for hypertension research and management by identifying a specific enzymatic defect.