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Related Experiment Videos

Strain differences in convulsions induced by alarm substance

E L Abel1

  • 1Department of Obstetrics and Gynecology and Fetal Alcohol Research Center, Wayne State University, Detroit, MI 48201.

Pharmacology, Biochemistry, and Behavior
|July 1, 1993
PubMed
Summary

Rats convulsed more in soiled water after imipramine treatment when the water was contaminated by Sprague-Dawley rats, indicating strain-specific alarm substance potency. This response was dose-dependent.

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Area of Science:

  • Neuroscience
  • Animal Behavior

Background:

  • The forced swim test reveals behavioral despair in rats, with immobility decreasing in soiled water.
  • Imipramine administration can induce convulsions in rats exposed to soiled water, suggesting a role for alarm substances.

Purpose of the Study:

  • To investigate the effect of imipramine on rat responses to soiled water from different strains.
  • To determine if rat strain influences the potency of alarm substances in soiled water.

Main Methods:

  • Four rat strains (Long-Evans, Sprague-Dawley, Wistar, Fischer) were injected with imipramine (20 or 30 mg/kg).
  • Rats were subsequently tested in water previously soiled by Sprague-Dawley or Wistar rats.
  • The incidence of convulsions was recorded.

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Main Results:

  • Significantly more rats convulsed when exposed to water soiled by Sprague-Dawley rats compared to Wistar rats.
  • A higher imipramine dose (30 mg/kg) led to more convulsions.
  • No significant differences in response to soiled water were observed across different rat strains.

Conclusions:

  • Alarm substances in soiled water can induce convulsions in imipramine-treated rats.
  • The potency of alarm substances varies between rat strains, with Sprague-Dawley rats producing a more potent substance.
  • Imipramine-induced convulsions are influenced by both the dose and the source of the alarm substance.