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Behavioral toxicity of anticholinesterases in primates: chronic physostigmine and soman interactions
D W Blick1, S A Miller, G C Brown
1Systems Research Laboratories Division of Arvin/Calspan, USAF Armstrong Laboratory, Brooks AFB, TX 78235-5000.
Pharmacology, Biochemistry, and Behavior
|July 1, 1993
Abstract:
Dose rates for continuous infusion of physostigmine salicylate required to inhibit 30 and 60% of normal serum cholinesterase activity in rhesus monkeys were determined. The effects of continuous physostigmine infusion at these dose rates on the behavioral toxicity of daily repeated low-dose soman were determined not to be deleterious; in fact, they were slightly (and variably) protective.