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[Acquired von Willebrand's disease]

S Berentsen¹, J Hammerstrøm

¹Medisinsk avedeling, Regionsykehuset i Trondheim.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|May 10, 1993

Summary

This study reports a patient with acquired von Willebrand's disease and Waldenström's macroglobulinemia, presenting with an acquired bleeding tendency. Laboratory results mimicked congenital von Willebrand's disease, highlighting a rare but significant association.

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Area of Science:

Hematology
Oncology
Immunology

Background:

Acquired von Willebrand's disease (AVWD) is a rare bleeding disorder.
It is often associated with lymphoproliferative disorders, malignancies, and autoimmune conditions.
Waldenström's macroglobulinemia is a rare B-cell lymphoma.

Observation:

A patient presented with an acquired bleeding tendency.
Laboratory findings were indistinguishable from congenital von Willebrand's disease.
The patient was diagnosed with both acquired von Willebrand's disease and Waldenström's macroglobulinemia.

Findings:

The co-occurrence of AVWD and Waldenström's macroglobulinemia is described.
Pathogenetic mechanisms for acquired von Willebrand's disease in this context are discussed.
The laboratory profile of AVWD can mimic the congenital form.

Implications:

AVWD should be considered in patients with unexplained bleeding, particularly those with lymphoproliferative, neoplastic, or autoimmune diseases.
This case underscores the importance of recognizing AVWD in the context of specific hematologic malignancies.
Further research is needed to elucidate the prevalence and pathogenesis of AVWD associated with Waldenström's macroglobulinemia.

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