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[Splenic neoplasms]

J T Pettersen1, O Modalsli, K Solheim

  • 1Gastroenterologisk avdeling, Ullevål sykehus, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|May 10, 1993
PubMed
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Primary and secondary spleen cancers are rare. This study details two cases: a primary angiosarcoma presenting with spleen rupture and breast cancer metastasis to the spleen. Both patients underwent splenectomy and adjuvant therapy.

Area of Science:

  • Oncology
  • Pathology

Background:

  • Splenic neoplasms, both primary and secondary, are exceptionally rare.
  • Angiosarcomas represent less than 1% of all sarcomas, with splenic angiosarcomas being particularly uncommon.

Observation:

  • Two cases of splenic malignancy are presented: a primary angiosarcoma causing spontaneous splenic rupture and a secondary carcinoma from breast cancer metastasis.
  • Spontaneous splenic rupture is a critical complication, occurring in approximately 30% of reported splenic angiosarcoma cases.

Findings:

  • Splenectomy followed by adjuvant oncological treatment was performed for both patients.
  • Malignant tumors frequently metastasize to the spleen, commonly originating from breast, lung, or ovarian primaries.

Implications:

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  • Splenic angiosarcoma carries a poor prognosis, irrespective of treatment.
  • Unexplained splenomegaly warrants consideration of metastatic neoplasm.