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Carbamazepine coadministration with fluoxetine or fluvoxamine
E Spina1, A Avenoso, A M Pollicino
1Institute of Pharmacology, University of Messina, Italy.
Therapeutic Drug Monitoring
|June 1, 1993
Abstract:
To study the potential interaction between carbamazepine (CBZ) and selective serotonin reuptake inhibitors, fluoxetine (20 mg/day) and fluvoxamine (100 mg/day) were administered for 3 weeks to eight and seven epileptic patients, respectively, on chronic CBZ treatment. No significant changes in steady-state plasma concentrations of CBZ and its active metabolite, carbamazepine-10,11-epoxide (CBZ-E) occurred, suggesting that CBZ metabolism is probably not affected by fluoxetine or fluvoxamine administration.