Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinal cone dysfunction of supernormal rod ERG type. Five new cases

T Rosenberg1, S E Simonsen

  • 1National Eye Clinic for The Visually Impaired, Hellerup, Denmark.

Acta Ophthalmologica
|April 1, 1993
PubMed
Summary

This study identifies a unique retinal dysfunction affecting cone and rod systems in five patients. Findings suggest a potential disruption in cyclic guanosine monophosphate metabolism impacting photoreceptors and retinal feedback.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of menstrual cycles with or without intercourse in women with no known subfertility.

Human reproduction open·2022
Same author

Does severe bleeding in HHT patients respond to intravenous bevacizumab? Review of the literature and case series.

Rhinology·2019
Same author

Validation of semiautomatic scoring of REM sleep without atonia in patients with RBD.

Sleep medicine·2018
Same author

Fertility treatments and adverse perinatal outcomes in a population-based sampling of births in Florida, Maryland, and Utah: a cross-sectional study.

BJOG : an international journal of obstetrics and gynaecology·2015
Same author

Prayer Marks in Immigrants from Bangladesh with Diabetes Who Live in Greece.

Journal of immigrant and minority health·2015
Same author

Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids.

CNS oncology·2015

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Molecular Biology

Background:

  • Retinal dysfunction can manifest in various forms, impacting visual processing.
  • Cone and rod photoreceptor systems have distinct roles in vision.
  • Electroretinography (ERG) is crucial for assessing retinal function.

Observation:

  • Five unrelated patients presented with clinical signs of retinal dysfunction.
  • Electroretinograms revealed primary cone system dysfunction with unusual rod involvement.
  • Elevated ERG b-wave threshold in dark adaptation and enhanced rod sensitivity at higher intensities were noted.

Findings:

  • Severe reduction in oscillatory potentials was observed in all patients.
  • The observed retinal dysfunction suggests a complex interplay between photoreceptors and inner retinal layers.

Related Experiment Videos

  • A hypothetical disturbance in cyclic guanosine monophosphate (cGMP) metabolism is proposed.

    • Implications:

    • This research may elucidate novel mechanisms underlying inherited retinal diseases.
    • Understanding cGMP metabolism disturbances could lead to new therapeutic targets.
    • The findings contribute to the differential diagnosis of retinal disorders.