Failure of prostaglandin induction in an obstructive müllerian abnormality

Failure of prostaglandins E2 and F2 alpha to induce labor for intrauterine fetal death is infrequent. The factors contributing to these failures remain unclear. We describe a case of failed induction with the use of a combination of vaginal prostaglandin E2 and systemic prostaglandin F2 alpha in a 24-week intrauterine fetal death in association with a noncommunicating rudimentary uterine horn. The implications of this müllerian abnormality for theories of parturition are discussed.