Related Experiment Video
Updated: Jul 15, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Effects of histamine-sensitizing factor and cortisol on lymphocyte adenyl cyclase responses
Abstract:
Levels of cyclic adenosime monophosphate (cAMP) in lymphocytes are regulated by beta-adrenergic agonists and PGE1. The effect of these agonists is potentiated by cortisol. Incubation of lymphocytes with histamine-sensitizing factor (HSF) leads to loss of response to epinephrine and PGE1. The response can be partially restored by cortisol. Incubation of lymphocytes with beta-adrenergic antagonists such as propranolol leads to the loss of beta-adrenergic agents but not PGE1. The inhibition by propranolol is not reversed by cortisol. These results suggest that the action of HSF and Bordetella pertussis vaccine is not mediated through the inhibition of beta-adrenergic receptors alone.
Related Concept Videos
Hypothalamic-Pituitary Axis
GPCRs Regulate Adenylyl Cylase Activity
Two...
Hormones of the Adrenal Glands
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology

