Related Experiment Videos
The role of the beta-subunit of initiation factor eIF-2 in initiation complex formation
A Flynn1, S Oldfield, C G Proud
1Department of Biochemistry, School of Medical Sciences, University of Bristol, UK.
Biochimica Et Biophysica Acta
|July 18, 1993
Abstract:
The functional properties of preparations of protein synthesis initiation factor eIF-2 which lack the beta-subunit (as confirmed immunologically) were compared with those of the heterotrimeric factor. The former can bind guanine nucleotides but not initiator tRNA, and also exhibits a substantially reduced rate of initiation factor eIF-2B-mediated GDP/GTP-exchange.