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Immunological responses in an infant after cyclosporine A exposure during pregnancy
Insights
Infants exposed to Cyclosporin A during pregnancy showed temporary low lymphocyte counts, particularly B-cells, which normalized within two years. CD8 cell counts remained low, but no persistent adverse immune effects were observed in this transplant recipient infant.
Area of Science:
- Immunology
- Transplantation medicine
- Neonatal care
Background:
- Pregnancy in organ transplant recipients is increasingly common.
- Cyclosporin A is a frequently used immunosuppressant in these patients.
- Limited data exist on the in utero effects of Cyclosporin A on infant immune development.
Abstract:
Pregnancy in transplant recipients is not uncommon. Cyclosporin A may be used as an immunosuppressive drug in these patients. Almost no data exist on the effects of cyclosporin A on the immune system of infants who have been exposed to this drug in utero. The infant of a liver transplant recipient was followed during the first 2 years of life. Shortly after birth all lymphocyte subsets were low, especially for B-cells. The distribution of lymphocytes returned to low normal ranges within the first 2 years of life, except for CD8 values that stayed below normal. There were no signs of persistent adverse effects of cyclosporin A on the functional integrity of the immune system.