[Effect of immunization of mice with human umbilical cord extract on micronucleus induction by cyclophosphane]

The influence of human umbilical cord extract (HUGE) on mutagenesis induces by cyclophosphamide in mice bone marrow cells was studied. It was shown that HUGE had no clastogenic property and decreased significantly the number of micronuclei in bone marrow cells of mice during 5 days after the last HUGE infection. We suppose that the antimutagenic effect is connected with interferon induction by HUGE.