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Newborn piglet model for campylobacteriosis
F K Babakhani1, G A Bradley, L A Joens
1Department of Veterinary Sciences, University of Arizona, Tucson 85721.
Infection and Immunity
|August 1, 1993
Summary
A new animal model using piglets successfully mimics human campylobacteriosis. This model reveals Campylobacter jejuni invades intestinal cells, causing lesions similar to human infections.
Area of Science:
- Veterinary Pathology
- Infectious Diseases
- Microbiology
Background:
- Campylobacteriosis is a significant human foodborne illness.
- Existing in vivo models for campylobacteriosis have limitations.
Purpose of the Study:
- To develop and validate an in vivo model for human campylobacteriosis.
- To investigate the pathological effects of Campylobacter jejuni in a susceptible host.
Main Methods:
- Oral challenge of colostrum-deprived newborn piglets with an invasive Campylobacter jejuni strain.
- Clinical observation and post-mortem examination including gross pathology and histopathology (light and transmission electron microscopy).
Main Results:
- Piglets exhibited clinical symptoms and histopathological lesions comparable to human campylobacteriosis.
- Gross lesions included edema, hyperemia, and mucus.
- Intracellular bacteria and epithelial cell damage were observed, primarily in the large intestine.
Conclusions:
- The developed piglet model effectively replicates key features of human campylobacteriosis.
- This model provides a valuable tool for studying Campylobacter jejuni pathogenesis and evaluating interventions.