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Related Experiment Videos

The mouse peritonitis model: present and future use

N Frimodt-Møller1

  • 1Department of Clinical Microbiology, Statens Seruminstitut, Copenhagen, Denmark.

The Journal of Antimicrobial Chemotherapy
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

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The mouse peritonitis model, established in 1935, remains crucial for in vivo antibiotic research. This model effectively evaluates antibiotic efficacy against various pathogens, aiding drug development before human trials.

Area of Science:

  • Pharmacology and Microbiology
  • Infectious Diseases
  • Experimental Therapeutics

Background:

  • The mouse peritonitis model was the first experimental animal model used in antibiotic research in 1935.
  • It has since been a standard in vivo model for testing antibiotics before progression to larger animals or humans.
  • While few bacteria are naturally virulent to mice, host defenses can be modulated to increase susceptibility to human pathogens.

Purpose of the Study:

  • To review the historical significance and continued utility of the mouse peritonitis model in antibiotic research.
  • To highlight the key parameters and factors investigated using this model.
  • To emphasize its ongoing importance in evaluating antibiotic efficacy in vivo.

Main Methods:

  • Historical review of the mouse peritonitis model's application in antibiotic research since 1935.

Related Experiment Videos

  • Discussion of common parameters for measuring antibiotic effect: bacterial counts and animal survival (e.g., 50% effective dose).
  • Consideration of host defense modulation to enhance susceptibility to human pathogens.

    • Main Results:

    • The model successfully demonstrated the efficacy of early sulfonamides against Streptococcus pyogenes.
    • Numerous significant factors influencing antibiotic effectiveness have been identified and validated using this model.
    • The model allows for the assessment of antibiotic effects on bacterial load and host survival.

    Conclusions:

    • The mouse peritonitis model has a long-standing history and proven track record in antibiotic research.
    • Its ability to assess antibiotic efficacy in vivo, combined with new understanding of pharmacokinetic correlations with humans, ensures its continued relevance.
    • This model is predicted to remain a vital tool for studying antibiotic effects.