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Gas chromatographic determination of meprobamate in human plasma
T Trenque1, D Lamiable, H Millart
1Laboratoire de Pharmacologie et de Toxicologie, Centre Hospitalier Régional et Universitaire, Reims, France.
Journal of Chromatography
|June 2, 1993
Abstract:
A simplified and rapid gas chromatographic method has been developed for the determination of meprobamate in human plasma. The procedure includes a single-step extraction of alkalinized sample with chloroform, and chromatography on a non-polar fused-silica capillary column with flame ionization detection. The method is accurate (97.7 +/- 5.7% at 20 mg/l) and precise (maximum coefficient of variation of 9.5%). It provides an alternative to existing methods and is particularly suitable for toxicological studies.