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Large keratoacanthomas treated with intralesional interferon alfa-2a
J J Grob1, F Suzini, M A Richard
1Service de Dermatologie, Hôpital Ste. Marguerite, Marseille, France.
Background:
Spontaneous involution of giant keratoacanthomas (KAs) can leave large scars or cause mutilation. Human papillomaviruses have recently been demonstrated in KAs. Intralesional interferon alfa-2a (IFN alfa-2a) has been shown to have activity against different epithelial tumors and to have an antiviral effect.
Objective:
This study was conducted to determine whether it was possible to stop extension of large KAs, to accelerate healing, and to obtain good cosmetic results with intralesional IFN alfa-2a.
Methods:
Six large KAs were treated with intralesional IFN alfa-2a.
Results:
Regression was obtained in five cases in 3 to 7 weeks with excellent cosmetic results. The main side effect was pain during injection.
Conclusion:
Our results suggest that this treatment hastens healing and limits scarring.