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Left ventricular hypertrophy: effect on survival

J M Sullivan1, R V Vander Zwaag, F el-Zeky

  • 1Division of Cardiovascular Disease, University of Tennessee, Memphis 38163.

Journal of the American College of Cardiology
|August 1, 1993
PubMed
Summary
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Left ventricular hypertrophy (LVH) independently reduces survival, even without coronary artery disease. This finding highlights LVH as a critical factor impacting patient outcomes and mortality risk.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Public Health

Background:

  • Left ventricular hypertrophy (LVH) is a known risk factor for coronary heart disease mortality.
  • The independent impact of LVH on survival, especially when coexisting with coronary artery stenosis, requires clarification.

Purpose of the Study:

  • To determine if left ventricular hypertrophy (LVH) has an independent adverse effect on patient survival.
  • To investigate the relationship between electrocardiographic (ECG) LVH, coronary artery disease, and long-term survival outcomes.

Main Methods:

  • Analysis of 4,824 patients who underwent coronary arteriography between 1972 and 1985.
  • Exclusion of patients who had undergone revascularization or had unstable angina, specific heart conditions, or non-LVH ECG changes.

Related Experiment Videos

  • Examination of the association between ECG-defined LVH, ST-T segment abnormalities, coronary artery disease, and five-year survival rates.

    • Main Results:

    • Five-year survival was significantly lower in patients with LVH (81.9%) compared to those without (90.2%).
    • LVH adversely affected survival irrespective of coronary artery disease presence (84.4% vs 94.5% without CAD; 81.0% vs 87.7% with CAD).
    • ST segment abnormalities did not significantly reduce survival in patients without coronary disease.

    Conclusions:

    • Electrocardiographic left ventricular hypertrophy (LVH) adversely impacts survival.
    • The adverse effect of LVH on survival is independent of the presence of coronary artery disease.
    • LVH is a significant prognostic indicator for mortality in cardiac patients.