Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colchicine and post-inflammatory adhesions in a rabbit model: a dose-response study

I Marcovici1, B A Rosenzweig, A I Brill

  • 1Department of Obstetrics and Gynecology, University of Illinois, Chicago.

Obstetrics and Gynecology
|August 1, 1993
PubMed
Summary

Colchicine effectively reduced inflammatory adhesions caused by Neisseria gonorrhoeae in rabbits. Higher doses of colchicine (the drug) showed a greater effect, but the benefit plateaued at 1 mg.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initial Experience With a Novel Bipolar Hysteroscopic Tissue Removal System: A pilot Study Using the Symphion<sup>®</sup> System to Perform Office Polypectomy and Myomectomy.

Journal of minimally invasive gynecology·2016
Same author

Use of diagnostic accuracy as a metric for evaluating laboratory proficiency with microarray assays using mixed-tissue RNA reference samples.

Pharmacogenomics·2008
Same author

Ovarian fibroma in the era of laparoscopic surgery: a general surgeon's experience.

Acta chirurgica Belgica·2008
Same author

Premature rupture of membranes, placenta increta, and hysterectomy in a pregnancy following endometrial ablation.

Journal of perinatology : official journal of the California Perinatal Association·2006
Same author

Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells.

Mutation research·2004
Same author

Loss of critical palindromic transgene promoter sequence in chemically induced Tg.AC mouse skin papillomas expressing transgene-derived mRNA.

Molecular carcinogenesis·2001

Area of Science:

  • Reproductive biology
  • Microbiology
  • Pharmacology

Background:

  • Pelvic inflammatory disease (PID) is a significant cause of infertility.
  • Neisseria gonorrhoeae is a primary pathogen implicated in PID and subsequent adhesion formation.
  • Adhesive disease can lead to serious reproductive health complications.

Purpose of the Study:

  • To investigate the dose-response relationship of colchicine in preventing Neisseria gonorrhoeae-induced inflammatory adhesions.
  • To establish the efficacy of varying colchicine dosages in a rabbit model.

Main Methods:

  • Rabbits were inoculated with Neisseria gonorrhoeae to induce intrauterine inflammation.
  • Four groups received daily intramuscular injections of colchicine (0.1, 0.5, 1, or 2 mg) for 14 days.

Related Experiment Videos

  • A control group received no treatment; adhesion formation was assessed post-treatment.

    • Main Results:

    • Colchicine administration demonstrated a dose-dependent reduction in the incidence and severity of adhesions.
    • A plateau effect was observed, indicating diminishing returns at higher colchicine doses (specifically beyond 1 mg).

    Conclusions:

    • Colchicine is effective in preventing inflammatory adhesions secondary to Neisseria gonorrhoeae in a rabbit model.
    • The therapeutic benefit of colchicine in reducing adhesion formation plateaus at a dose of 1 mg.