Related Experiment Videos
[Positive and negative controls on hematopoietic progenitor development: models and facts]
B Panterne1, A Hatzfeld, Y Q Zhou
1Laboratoire CNRS de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, UPR 272, IRSC, Villejuif, France.
Nouvelle Revue Francaise D'Hematologie
|June 1, 1993
Abstract:
The stochastic model of stem cell differentiation is in accord with experimental findings but does not explain hematopoietic homeostasis. We discuss how positive and negative controls by cytokines and inhibitors could maintain homeostasis, even though progenitor commitment towards the various hematopoietic lineages may be stochastic.