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NMR determination of trimethoprim and sulfamethoxazole in tablets and powders

M R Rodriguez, M T Pizzorno, S M Albonico

Journal of Pharmaceutical Sciences

|January 1, 1977

Abstract:

An NMR spectroscopic method for the determination of mixtures of trimethoprim and sulfamethoxazole is described. Spectra are determined in dimethylsulfoxide-d6, containing 1,4-dinitrobenzene as an internal standard. Both synthetic mixtures and commercial formulations were assayed, and the results were compared to those obtained using the BP procedure.

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