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[Sensitive polyneuropathy and diabetic cardiovascular dysautonomy]
C Goulon-Goeau1, A Fontbonne, G Saïd
1Service de Neurologie, CHU de Bicêtre, Université Paris XI, France.
Revue Neurologique
|January 1, 1993
Summary
Diabetic neuropathy can affect cardiocirculatory function. This study found a strong correlation between the extent of sensory loss and impaired autonomic function tests in patients with diabetic sensory neuropathy.
Area of Science:
- Neurology
- Cardiology
- Diabetology
Context:
- Diabetic distal symmetrical sensory neuropathy is a common complication.
- Autonomic dysfunction can occur in diabetic neuropathy.
- Understanding the relationship between neuropathy severity and autonomic function is crucial.
Purpose:
- To correlate the extent of sensory loss in diabetic patients with distal symmetrical sensory neuropathy with alterations in cardiocirculatory tests.
- To investigate the relationship between sensory loss level and autonomic nervous system function.
Summary:
- A clinical and physiological study was conducted on 56 diabetic patients with distal symmetrical sensory neuropathy.
- Cardiovascular tests including blood pressure, heart rate variations, Valsalva's maneuver, and respiratory R-R intervals were performed.
- A highly significant correlation (p < 0.001) was found between the level of sensory loss and impairment of all three physiological tests, particularly when sensory loss extended above the knee.
Impact:
- The findings suggest that severe neuropathy, indicated by sensory loss above the knee, is associated with impaired cardiocirculatory tests.
- While a strong correlation exists, it may not definitively prove that cardiocirculatory impairment in diabetic neuropathy is solely a length-dependent phenomenon.
- This research contributes to understanding the multifaceted nature of diabetic neuropathy and its systemic effects.