Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An improved method for O-demethylation of codeine

J A Lawson, J I DeGraw

    Journal of Medicinal Chemistry
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Investigation of the use of urinary proteomics in the prediction of childhood asthma.

    Respiratory medicine·2026
    Same author

    Farm Exposures and Allergic Disease Among Children Living in a Rural Setting.

    Journal of agromedicine·2023
    Same author

    A scoping review of the roles, training, and impact of community health workers in oral health.

    Community dental health·2021
    Same author

    Editor's Choice - Nationwide Analysis of Patients Undergoing Iliac Artery Aneurysm Repair in the Netherlands.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2020
    Same author

    Divergent trends in the prevalence of asthma-like symptoms and asthma in a developing country: three repeated surveys between 2002 and 2016.

    Allergologia et immunopathologia·2020
    Same author

    What children say and clinicians hear: accounts relating to incisor hypomineralisation of cosmetic concern.

    European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2019

    Researchers achieved an 80% yield of morphine from codeine O-demethylation using sodium propylmercaptide in dimethylformamide. The same method was unsuccessful for thebaine demethylation.

    Area of Science:

    • Organic Chemistry
    • Medicinal Chemistry

    Background:

    • Codeine and thebaine are key opioid alkaloids.
    • Efficient chemical synthesis routes are crucial for pharmaceutical development.

    Purpose of the Study:

    • To investigate the O-demethylation of codeine to morphine.
    • To explore the reactivity of thebaine under similar conditions.

    Main Methods:

    • O-demethylation of codeine using sodium propylmercaptide in dimethylformamide at 125°C.
    • Treatment of thebaine under identical reaction conditions.

    Main Results:

    • Morphine was synthesized from codeine with an 80% yield.
    • The O-demethylation of thebaine was unsuccessful.

    Related Experiment Videos

    Conclusions:

    • Sodium propylmercaptide is an effective reagent for the O-demethylation of codeine to morphine.
    • Thebaine exhibits different reactivity compared to codeine under these specific demethylation conditions.