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Related Experiment Videos

Fetal renal biopsy: technique development

W A Campbell1, H T Yamase, C A Salafia

  • 1Department of Obstetrics and Gynecology, University of Connecticut Health Center, John Dempsey Hospital, Farmington.

Fetal Diagnosis and Therapy
|March 1, 1993
PubMed
Summary
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Determining the optimal needle biopsy gauge for fetal and neonatal kidney histology is crucial. Larger gauges (14- and 16-gauge) yield more adequate renal parenchyma samples than smaller ones.

Area of Science:

  • Pediatric Pathology
  • Nephrology
  • Histopathology

Background:

  • Accurate histologic evaluation of fetal and neonatal kidneys is essential for diagnosis and research.
  • Determining the optimal needle biopsy technique for obtaining adequate renal parenchyma is critical.

Purpose of the Study:

  • To evaluate different needle biopsy catheter gauges for obtaining suitable renal parenchyma from fetal and neonatal kidneys for histologic assessment.

Main Methods:

  • Kidney specimens from 11 fetuses/neonates (16-40 weeks gestation) were used.
  • Needle biopsies were performed using 20-, 18-, 16-, and 14-gauge catheters.
  • Biopsy adequacy was graded based on the presence of normal renal parenchyma features.

Main Results:

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  • 84% of biopsies were adequate (cortex or medulla present).
  • Larger gauges (14- and 16-gauge) yielded significantly higher rates of completely adequate biopsies (79% and 69%) compared to smaller gauges (35% and 25%).
  • Smaller gauge catheters were associated with core sample disruption.

Conclusions:

  • Adequate fetal and neonatal kidney biopsies can be obtained using needle biopsy techniques.
  • Larger gauge catheters (14- and 16-gauge) are recommended for improved sample adequacy.
  • Further investigation into sampling techniques is needed to minimize disruption and optimize tissue yield.