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Intractable singultus: a diagnostic and therapeutic challenge
British Journal of Neurosurgery
|January 1, 1993
Summary
Hiccup (singultus) is a diaphragm spasm involving the phrenic nerve. Baclofen shows promise as a new treatment for chronic, intractable hiccups, potentially stemming from brainstem seizures.
Area of Science:
- Neurology
- Respiratory Physiology
Background:
- Hiccup (singultus) involves involuntary diaphragmatic contractions and glottic closure.
- It's mediated by the phrenic, vagus, and sympathetic nerves.
- The neural pathways involve the brainstem, hypothalamus, and respiratory centers.
Observation:
- Chronic intractable hiccup may be linked to brainstem seizures.
- Three cases illustrate the potential of baclofen for treatment.
Findings:
- Baclofen may be an effective remedy for persistent hiccups.
- This suggests a neurological basis for intractable hiccup.
Implications:
- Baclofen offers a potential therapeutic option for difficult-to-treat hiccup cases.
- Further research into brainstem seizures and hiccup is warranted.