A new method to study the efficiency of third generation blood filters
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Updated: Nov 8, 2026

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing
Published on: February 13, 2016
M Sivakumaran1, D R Norfolk, K E Major
1Department of Haematology, Leicester Royal Infirmary.
Abstract:
In order to study the efficiency of third generation blood filters we have devised a new method using 3 microns pore size polycarbonate filter membranes and a filtration chamber to trap leucocytes passing through the blood filter. The method has enabled us to make two important observations: (1) The filters function very efficiently at the start but the efficiency diminishes progressively with time. (2) When the blood flow through the filter is retarded, due to defective priming and/or filter malfunction, the filters fail even at the outset of the transfusion.

